特异性
This antibody detects endogenous levels of p120 Catenin
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
来源
Monoclonal, Rabbit,IgG
稀释比例
Ready to use for IHC Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
2°C to 8°C/1 year,Ship by ice bag
其他名称
Cadherin associated Src substRate ; Cadherin-associated Src substRate ; CAS ; Catenin ; cadherin associated protein ; delta 1 ; Catenin delta 1 ; Catenin delta ; Catenin delta-1 ; CTND1_HUMAN ; CTNND 1 ; CTNND ; CTNND1 ; delta 1 Catenin ; KIAA0384 ; p120 ; P120 CAS ; p120 catenin ; P120 CTN ; p120 ; cas ; p120 ; ctn ; P120CAS ; P120CTN
背景
catenin delta 1(CTNND1) Homo sapiens This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010],
功能
Alternative products:Experimental confirmation may be lacking for some isoforms,Disease:May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated.,Domain:A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.,Function:Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.,induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.,PTM:Phosphorylated.,similarity:Belongs to the beta-catenin family.,similarity:Contains 10 ARM repeats.,subcellular location:Interaction with GLIS2 promotes nuclear translocation.,subunit:Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2.,tissue specificity:Expressed in vascular endothelium.,
