组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
背景
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
功能
Catalytic activity:ATP + D-fructose = ADP + D-fructose 1-phosphate.,Caution:Form C has not yet been fully sequenced in its N-terminal (from 1-69).,Disease:Defects in KHK are the cause of fructosuria [MIM:229800]. Fructosuria is a benign defect of intermediary metabolism.,enzyme regulation:Requires potassium. Inhibition by ADP.,pathway:Carbohydrate metabolism; fructose metabolism.,similarity:Belongs to the carbohydrate kinase pfkB family.,subunit:Dimer of A-A, A-C or C-C.,tissue specificity:Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.,
