免疫原
Synthetic peptide. This information is considered to be commercially sensitive.
纯化工艺
Affinity purification
储存
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified
on the Certificate of Analysis), pH 7.3.
其他名称
GH; GHN; GH-N; GHB5; IGHD2; hGH-N; IGHD1A; IGHD1B; GH1
背景
The protein encoded by this gene is a member of the somatotropin/prolactin family of
hormones which play an important role in growth control. The gene, along with four other
related genes, is located at the growth hormone locus on chromosome 17 where they are
interspersed in the same transcriptional orientation; an arrangement which is thought to
have evolved by a series of gene duplications. The five genes share a remarkably high
degree of sequence identity. Alternative splicing generates additional isoforms of each of the
five growth hormones, leading to further diversity and potential for specialization. This
particular family member is expressed in the pituitary but not in placental tissue as is the
case for the other four genes in the growth hormone locus. Mutations in or deletions of the
gene lead to growth hormone deficiency and short stature.
