基因名称(Gene Name)
ISG20 HEM45
免疫原
Synthesized peptide derived from human ISG20 AA range: 87-137
特异性
This antibody detects endogenous levels of ISG20 at Human/Mouse
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景
potassium calcium-activated channel subfamily N member 1(KCNN1) Homo sapiens Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.,cofactor:Manganese.,function:Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.,induction:Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level.,miscellaneous:Stable and constitutive expression confers resistance to vesicular stomatitis virus (VSV), influenza virus, and encephalomyocarditis virus (EMCV) infection in HeLa cells, providing an alternative antiviral pathway against RNA genomic viruses. Up regulated by E2 in estrogen receptor-positive breast cancer lines.,similarity:Belongs to the exonucl
