基因名称(Gene Name)
KDM5A JARID1A RBBP2 RBP2
蛋白名称
Lysine-specific demethylase 5A (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2)
免疫原
The specific immunogen used to produce this antibody is proprietary information.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
KDM5A JARID1A RBBP2 RBP2;Lysine-specific demethylase 5A (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2)
背景
This gene encodes a member of the Jumonji , AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins , including retinoblastoma protein , and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq , Aug 2013] ,
功能
cofactor:Fe (2+) . ,Function:Histone demethylase that specifically demethylates 'Lys-4' of histone H3 , thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' , H3 'Lys-27' , H3 'Lys-36' , H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. ,similarity:Belongs to the JARID1 histone demethylase family. ,similarity:Contains 1 ARID domain. ,similarity:Contains 1 JmjC domain. ,similarity:Contains 1 JmjN domain. ,similarity:Contains 3 PHD-type zinc fingers. ,subunit:Interacts with the viral protein-binding domain of RB1. Interacts with ESR1 , MYC , MYCN and LMO2. ,
