蛋白名称
C-C chemokine receptor type 2
免疫原
The specific immunogen used to produce this antibody is proprietary information.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
CCR2;C-C chemokine receptor type 2;CCR2 ;
CMKBR2 ;
C-C chemokine receptor type 2 ;
C-C CKR-2 ;
CC-CKR-2 ;
CCR-2 ;
CCR2 ;
Monocyte chemoattractant protein 1 receptor ;
MCP-1-R ;
CD192
背景
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 , a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq , Mar 2009] ,
功能
Function:Receptor for the MCP-1 , MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. ,online information:CC chemokine receptors entry ,polymorphism:Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423]. ,PTM:N-glycosylated. ,similarity:Belongs to the G-protein coupled receptor 1 family. ,subunit:Binds to HIV-1 Tat. ,
