蛋白名称
Cyclin-dependent kinase inhibitor 1C
免疫原
The specific immunogen used to produce this antibody is proprietary information.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:200-1:1000; WB 1:5000-1:20000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
CDKN1C;Cyclin-dependent kinase inhibitor 1C;Beckwith Wiedemann syndrome ;
BWCR ;
BWS ;
CDKI ;
CDKN 1C ;
CDKN1C ;
CDN1C_HUMAN ;
Cyclin dependent kinase inhibitor 1C ;
Cyclin dependent kinase inhibitor p57 ;
Cyclin-dependent kinase inhibitor 1C ;
Cyclin-dependent kinase inhibitor p57 ;
KIP 2 ;
KIP2 ;
p57 ;
p57 Kip 2 ;
p57KIP2 ;
WBS
背景
P57kip2 is a cell cycle inhibitor and tumor suppressor. The gene is mainly located on the mother's chromosome 11. By blocking the G1 / S phase transition in the cell cycle , we can realize the negative regulation of the cell cycle , and then prevent cell proliferation and tumor formation. In complete hydatidiform mole , there is a lack of maternal gene and p57 negative expression , while in partial hydatidiform mole , there are genes of both parents and p57 positive expression , which can be used for the study of early hydatidiform mole pregnancy.
功能
Disease:Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele) , pre- and postnatal overgrowth , and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors. ,Disease:Defects in CDKN1C are involved in tumor formation. ,Function:Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2 , cyclin D2-CDK4 , and cyclin A-CDK2) and , to lesser extent , of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. ,similarity:Belongs to the CDI family. ,tissue specificity:Expressed in the heart , brain , lung , skeletal muscle , kidney , pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. ,
