免疫原
The specific immunogen used to produce this antibody is proprietary information.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:100-1:200; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
tlr7;PRO285 ;TLR 7 ;Tlr7 ;TLR7_HUMAN ;Toll like receptor 7 ;Toll-like receptor 7 ;UNQ248.
背景
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents , and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung , placenta , and spleen , and lies in close proximity to another family member , TLR8 , on chromosome X. [provided by RefSeq , Jul 2008] ,
功能
Function:Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6 , leading to NF-kappa-B activation , cytokine secretion and the inflammatory response. ,similarity:Belongs to the Toll-like receptor family. ,similarity:Contains 1 TIR domain. ,similarity:Contains 27 LRR (leucine-rich) repeats. ,subunit:Binds MYD88 via their respective TIR domains. ,tissue specificity:Detected in brain , placenta , spleen , stomach , small intestine , lung and in plasmacytoid pre-dendritic cells. ,
