蛋白名称
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
特异性
This antibody detects endogenous levels of PGP9.5
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
来源
Monoclonal, Rabbit,IgG
稀释比例
Ready to use for IHC Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
2°C to 8°C/1 year,Ship by ice bag
其他名称
Epididymis luminal protein 117 ; Epididymis secretory protein Li 53 ; HEL 117 ; HEL S 53 ; NDGOA ; Neuron cytoplasmic protein 9.5 ; OTTHUMP00000218137 ; OTTHUMP00000218139 ; OTTHUMP00000218140 ; OTTHUMP00000218141 ; Park 5 ; PARK5 ; PGP 9.5 ; PGP9.5 ; PGP95 ; Protein gene product 9.5 ; Ubiquitin C terminal esterase L1 ; Ubiquitin C terminal hydrolase ; Ubiquitin C terminal hydrolase L1 ; Ubiquitin carboxyl terminal esterase L1 ; Ubiquitin carboxyl terminal hydrolase isozyme L1 ; Ubiquitin carboxyl-terminal hydrolase isozyme L1 ; Ubiquitin thioesterase L1 ; Ubiquitin thiolesterase ; Ubiquitin thiolesterase L1 ; UCH-L1 ; UCHL1 ; UCHL1_HUMAN
背景
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009],
功能
Catalytic activity:Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).,Disease:Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles.,Function:Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.,miscellaneous:In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.,online information:Ubiquitin carboxy-terminal hydrolase L1 entry,PTM:O-glycosylated.,similarity:Belongs to the peptidase C12 family.,subunit:Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.,tissue specificity:Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary.,
