基因名称(Gene Name)
CDH16 UNQ695/PRO1340
特异性
This antibody detects endogenous levels of KSP-Cadherin
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
来源
Monoclonal, Rabbit,IgG
稀释比例
Ready to use for IHC Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
2°C to 8°C/1 year,Ship by ice bag
其他名称
CDH16 ; Cadherin-16 ; Kidney-specific cadherin ; Ksp-cadherin
背景
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011],
功能
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 6 cadherin domains.,tissue specificity:Kidney specific.,
