特异性
This antibody detects endogenous levels of Ki-67
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:100-500; WB 1:500-1000; ELISA 1:5000-20000 Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
Antigen identified by monoclonal Ki 67 ; Antigen identified by monoclonal Ki-67 ; Antigen KI-67 ; Antigen KI67 ; Antigen Ki67 ; KI67_HUMAN ; KIA ; Marker of prolifeRation Ki-67 ; MIB 1 ; MIB ; MKI67 ; PPP1R105 ; ProlifeRation marker protein Ki-67 ; ProlifeRation related Ki 67 antigen ; Protein phosphatase 1 regulatory subunit 105 ; RP11-380J17.2
背景
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009],
功能
developmental stage:Expression of this antigen occurs preferentially during late G1, S, G2 and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected.,Function:Thought to be required for maintaining cell proliferation.,online information:Ki-67 entry,similarity:Contains 1 FHA domain.,subcellular location:Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.,subunit:Interacts with KIF15. Binds through the FHA domain to MKI67IP.,
