蛋白名称
Gastric mucin 6;Gastric Mucin;Gastric mucin-6;MUC 6;MUC-6;Muc6;MUC6 Fragment;MUC6 mucin;MUC6 mucin Fragment;MUC6_HUMAN;Mucin 6;Mucin 6 gastric;Mucin 6 oligomeric mucus/gel forming;Mucin glycoprotein Fragment;Mucin-6;Secretory mucin MUC6 Fragment
特异性
This antibody detects endogenous levels of Gastrin
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
来源
Monoclonal, Rabbit,IgG
稀释比例
Ready to use for IHC Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
2°C to 8°C/1 year,Ship by ice bag
其他名称
Gastric mucin 6 ; Gastric Mucin ; Gastric mucin-6 ; MUC 6 ; MUC-6 ; Muc6 ; MUC6 Fragment ; MUC6 mucin ; MUC6 mucin Fragment ; MUC6_HUMAN ; Mucin 6 ; Mucin 6 gastric ; Mucin 6 oligomeric mucus/gel forming ; Mucin glycoprotein Fragment ; Mucin-6 ; Secretory mucin MUC6 Fragment
背景
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008],
功能
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.,online information:Gastrin entry,PTM:Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.,PTM:Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.,similarity:Belongs to the gastrin/cholecystokinin family.,
