基因名称(Gene Name)
FSCN1 FAN1 HSN SNL
蛋白名称
Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)
特异性
This antibody detects endogenous levels of Fascin
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
来源
Monoclonal, Rabbit,IgG
稀释比例
Ready to use for IHC Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
2°C to 8°C/1 year,Ship by ice bag
其他名称
55 kDa actin bundling protein ; 55 kDa actin-bundling protein ; Actin bundling protein ; actin bundling protein, 55-KD ; FAN 1 ; FAN1 ; Fascin 1 ; Fascin actin bundling protein 1 ; Fascin ; Fascin homolog 1 actin bundling protein ; Strongylocentrotus purpuRatus ; Fascin homolog 1 ; Fascin, sea urchin, homolog of, 1 ; Fascin1 ; FLJ38511 ; FSCN 1 ; FSCN1 ; FSCN1_HUMAN ; HSN ; p55 ; Singed ; Drosophila ; like ; sea urchin fascin homolog like ; Singed drosophila homolog like ; Singed like ; fascin homolog sea urchin ; Drosophila ; Singed like ; fascin homolog sea urchin ; Singed like protein ; Singed, drosophila, homolog of ; Singed-like protein ; SNL ; Strongylocentrotus purpuRatus
背景
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011],
功能
Disease:Marks and mediates breast cancer metastasis to the lungs. FSCN1 is not functionally validated but achieves the highest statistical significance (P less than 0.000001). Those subjects expressing the lung metastasis signature have a significantly poorer lung metastasis-free survival, but not bone metastasis-free survival, compared to subjects without the signature.,Function:Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, and stress fibers.,PTM:Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.,similarity:Belongs to the fascin family.,subunit:Associates with beta-catenin.,tissue specificity:Ubiquitous.,
