特异性
This antibody detects endogenous levels of COX2
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
来源
Monoclonal, Rabbit,IgG
稀释比例
Ready to use for IHC Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
2°C to 8°C/1 year,Ship by ice bag
其他名称
COX 2 ; COX-2 ; COX2 ; Cyclooxygenase 2 ; Cyclooxygenase 2b ; Cyclooxygenase ; Cyclooxygenase-2 ; Cyclooxygenase2 ; fj02a10 ; Glucocorticoid-regulated inflammatory cyclooxygenase ; Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase ; GRIPGHS ; hCox 2 ; Macrophage activation-associated marker protein P71/73 ; OTTHUMP00000033524 ; PES-2 ; PGG/HS ; PGH synthase 2 ; PGH2_HUMAN ; PGHS 2 ; PGHS-2 ; PGHS2 ; PHS 2 ; PHS II ; PHS2 ; Prostaglandin endoperoxide synthase 2 ; prostaglandin G/H synthase and cyclooxygenase ; Prostaglandin endoperoxide synthase 2 ; Prostaglandin G/H synthase 2 ; Prostaglandin G/H synthase 2 precursor ; Prostaglandin G/H synthase and cyclooxygenase ; Prostaglandin G/H synthase ; Prostaglandin H2 synthase 2 ; prostaglandin-endoperoxide synthase 2 ; prostaglandin G/H synthase and cyclooxygenase ; Prostaglandin-endoperoxide synthase 2 ; PTGS2 ; ptgs2a ; TIS10 ; TIS10 protein ; unp1239 ; wu:fj02a10
背景
Prostaglandin-endoperoxide synthase , also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009],
功能
Catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,Disease:Likely to play a role in inflammatory diseases such as rheumatoid arthritis.,Function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.,induction:By cytokines and mitogens.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,
