基因名称(Gene Name)
POU2AF1 OBF1
蛋白名称
POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
特异性
This antibody detects endogenous levels of BOB.1
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
来源
Monoclonal, Rabbit,IgG
稀释比例
Ready to use for IHC Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
2°C to 8°C/1 year,Ship by ice bag
其他名称
B cell Oct binding protein 1 ; B cell specific coactivator OBF 1 ; B cell specific coactivator OBF1 ; B-cell-specific coactivator OBF-1 ; BOB 1 ; BOB-1 ; OBF 1 ; OBF1 ; OBF1_HUMAN ; OCA B ; OCA-B ; OCAB ; OCT binding factor 1 ; OCT-binding factor 1 ; POU class 2 associating factor 1 ; POU domain class 2 associating factor 1 ; POU domain class 2-associating factor 1 ; Pou2af1
背景
BOB.1 is a transcription activating factor necessary for the formation of follicular germinal center and the production of immunoglobulin. It works together with Oct-2 and is highly expressed in granulocytes of spleen and peripheral blood. It is mainly used for the typing of Hodgkin's lymphoma, mainly nodular lymphocytes. Hodgkin's lymphoma is positive and classical Hodgkin's lymphoma is negative.
功能
Disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.,Function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,
