特异性
This antibody detects endogenous levels of CD14
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
来源
Monoclonal, Rabbit,IgG
稀释比例
Ready to use for IHC Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
2°C to 8°C/1 year,Ship by ice bag
其他名称
CD 14 ; CD_antigen=CD14 ; CD14 ; CD14 antigen ; CD14 molecule ; CD14_HUMAN ; LPS-R ; Mo2 ; Monocyte differentiation antigen CD14 ; Monocyte differentiation antigen CD14 urinary form ; Monocyte differentiation antigen CD14, membrane-bound form ; Myeloid cell specific leucine rich glycoprotein ; Myeloid cell-specific leucine-rich glycoprotein
背景
The protein encoded byThis gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediateThe innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encodingThe same protein. [provided by RefSeq, Mar 2010],
功能
Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.,online information:CD14 entry,similarity:Contains 11 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.,
