蛋白名称
alpha polypeptide (p32);CD_antigen=CD8a;CD8;CD8 antigen alpha polypeptide;CD8 antigen alpha polypeptide (p32);CD8 antigen, alpha polypeptide (p32);CD8a;CD8A antigen;CD8A molecule;CD8A_HUMAN;Leu2;Leu2 T lymphocyte antigen;Ly 2;Ly 35;Ly B;Ly2;Ly3;Ly35;LyB;Lyt 2.1 lymphocyte differentiation antigen (AA at 100);LYT3;MAL;OKT8 T cell antigen;OTTHUMP00000160760;OTTHUMP00000160764;OTTHUMP00000203528;OTTHUMP00000203721;p32;T cell antigen Leu2;T cell co receptor;T lymphocyte differentiation antigen T8/Leu 2;T-cell surface glycoprotein CD8 alpha chain;T-cell surface glycoprotein Lyt 2;T-lymphocyte differentiation antigen T8/Leu-2;T8 T cell antigen;T8/Leu-2 T-lymphocyte differentiation antigen
特异性
This antibody detects endogenous levels of CD8
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
来源
Monoclonal, Rabbit,IgG
稀释比例
Ready to use for IHC Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
2°C to 8°C/1 year,Ship by ice bag
其他名称
alpha polypeptide (p32) ; CD_antigen=CD8a ; CD8 ; CD8 antigen alpha polypeptide ; CD8 antigen alpha polypeptide (p32) ; CD8 antigen, alpha polypeptide (p32) ; CD8a ; CD8A antigen ; CD8A molecule ; CD8A_HUMAN ; Leu2 ; Leu2 T lymphocyte antigen ; Ly 2 ; Ly 35 ; Ly B ; Ly2 ; Ly3 ; Ly35 ; LyB ; Lyt 2.1 lymphocyte differentiation antigen (AA at 100) ; LYT3 ; MAL ; OKT8 T cell antigen ; OTTHUMP00000160760 ; OTTHUMP00000160764 ; OTTHUMP00000203528 ; OTTHUMP00000203721 ; p32 ; T cell antigen Leu2 ; T cell co receptor ; T lymphocyte differentiation antigen T8/Leu 2 ; T-cell surface glycoprotein CD8 alpha chain ; T-cell surface glycoprotein Lyt 2 ; T-lymphocyte differentiation antigen T8/Leu-2 ; T8 T cell antigen ; T8/Leu-2 T-lymphocyte differentiation antigen
背景
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions withinThe immune system.The CD8 antigen acts as a coreceptor withThe T-cell receptor onThe T lymphocyte to recognize antigens displayed by an antigen presenting cell inThe context of class I MHC molecules.The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.This gene encodesThe CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found forThis gene. [provided by RefSeq, Nov 2011],
功能
disease:Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.,function:Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.,online information:CD8 entry,online information:CD8A mutation db,PTM:All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterdimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.,
