蛋白名称
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
特异性
This antibody detects endogenous levels of ICAM-1
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
来源
Monoclonal, Rabbit,IgG
稀释比例
Ready to use for IHC Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
纯化工艺
Recombinant Expression and Affinity purified
储存
2°C to 8°C/1 year,Ship by ice bag
其他名称
Antigen identified by monoclonal BB2 ; BB 2 ; BB2 ; CD 54 ; CD_antigen=CD54 ; CD54 ; Cell surface glycoprotein P3.58 ; Human rhinovirus receptor ; ICAM 1 ; ICAM-1 ; ICAM1 ; ICAM1_HUMAN ; intercellular adhesion molecule 1 (CD54) ; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor ; Intercellular adhesion molecule 1 ; Major group rhinovirus receptor ; MALA 2 ; MALA2 ; MyD 10 ; MyD10 ; P3.58 ; Surface antigen of activated B cells ; Surface antigen of activated B cells, BB2
背景
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells ofThe immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008],
功能
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.,
