基因名称(Gene Name)
CTGF CCN2 HCS24 IGFBP8
蛋白名称
Connective tissue growth factor (CCN family member 2) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
WB 1:500-2000; ELISA 1:5000-20000; IP 1:50-200; IF 1:200-1:1000;
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
CTGF ; CCN2 ; HCS24 ; IGFBP8 ; Connective tissue growth factor ; CCN family member 2 ; Hypertrophic chondrocyte-specific protein 24 ; Insulin-like growth factor-binding protein 8 ; IBP-8 ; IGF-binding protein 8 ; IGFBP-8
背景
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009],
功能
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 VWFC domain.,subunit:Monomer.,
