基因名称(Gene Name)
PPP2CA;PPP2CB
蛋白名称
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;PP2A-beta;PP2A-alpha;Replication protein C;RP-C;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
PP2A A ; PP2A alpha ; PP2A B ; PP2A beta ; PP2A-alpha ; PP2A-beta ; PP2AA_HUMAN ; PP2Aalpha ; PP2AB_HUMAN ; PP2Abeta ; PP2Ac ; PP2CA ; PP2Calpha ; PP2CB ; PPP2CA ; PPP2CB ; Protein phosphatase 2 catalytic subunit alpha isoform ; Protein phosphatase 2 catalytic subunit beta isoform ; Protein phosphatase type 2A catalytic subunit ; Replication protein C ; RP C ; RP-C ; RPC ; Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform ; Serine/threonine protein phosphatase 2A catalytic subunit beta isoform ; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform ;
背景
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008],
功能
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'.
