基因名称(Gene Name)
DOHH;HLRC1
蛋白名称
Deoxyhypusine hydroxylase;hDOHH;Deoxyhypusine dioxygenase;Deoxyhypusine monooxygenase;HEAT-like repeat-containing protein 1;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
WB 1:1000-5000; IP 1:50-100
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
DOHH ; HLRC1 ; Deoxyhypusine hydroxylase ; hDOHH ; Deoxyhypusine dioxygenase ; Deoxyhypusine monooxygenase ; HEAT-like repeat-containing protein 1 ;
背景
This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
功能
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16371467, PubMed:16533814, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity). {ECO:0000250|UniProtKB:Q99LN9, ECO:0000255|HAMAP-Rule:MF_03101, ECO:0000269|PubMed:16371467, ECO:0000269|PubMed:16533814, ECO:0000269|PubMed:19706422}.
