基因名称(Gene Name)
RBMY1A1;RBM1;RBM2;YRRM1;YRRM2
蛋白名称
RNA-binding motif protein, Y chromosome, family 1 member A1;RNA-binding motif protein 1;RNA-binding motif protein 2;Y chromosome RNA recognition motif 1;hRBMY;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
WB 1:1000-5000; IHC 1:100-300 Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
RBMY1A1 ; RBM1 ; RBM2 ; YRRM1 ; YRRM2 ; RNA-binding motif protein, Y chromosome, family 1 member A1 ; RNA-binding motif protein 1 ; RNA-binding motif protein 2 ; Y chromosome RNA recognition motif 1 ; hRBMY ;
背景
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein is thought to function as a splicing regulator during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]
功能
RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:8269511}.
