基因名称(Gene Name)
IRAG2;JAW1;LRMP
蛋白名称
Inositol 1,4,5-triphosphate receptor associated 2;Lymphoid-restricted membrane protein;Protein Jaw1; [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2]
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
WB 1:1000-5000; IHC 1:100-300; ICC/IF 1:100-300; FC 1:100-300 Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
IRAG2 ; JAW1 ; LRMP ; Inositol 1,4,5-triphosphate receptor associated 2 ; Lymphoid-restricted membrane protein ; Protein Jaw1 ; [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] ;
背景
The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
功能
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}.
