蛋白名称
Kelch-like protein 6
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
WB 1:1000-5000; ICC/IF 1:100-300; IP 1:50-100
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
KLHL6 ; Kelch-like protein 6 ;
背景
This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
功能
Involved in B-lymphocyte antigen receptor signaling and germinal center formation. {ECO:0000250}.
