蛋白名称
TATA box-binding protein-associated factor RNA polymerase I subunit C;RNA polymerase I-specific TBP-associated factor 110 kDa;TAFI110;TATA box-binding protein-associated factor 1C;TBP-associated factor 1C;Transcription initiation factor SL1/TIF-IB subunit C;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
WB 1:1000-5000; IP 1:50-100
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
TAF1C ; TATA box-binding protein-associated factor RNA polymerase I subunit C ; RNA polymerase I-specific TBP-associated factor 110 kDa ; TAFI110 ; TATA box-binding protein-associated factor 1C ; TBP-associated factor 1C ; Transcription initiation factor SL1/TIF-IB subunit C ;
背景
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]
功能
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:15970593}.
