基因名称(Gene Name)
SLC6A5,GLYT2,NET1
蛋白名称
Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
背景
This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
功能
Sodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349). Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:9845349). May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:9845349). {ECO:0000269|PubMed:10381548, ECO:0000269|PubMed:10606742, ECO:0000269|PubMed:16751771, ECO:0000269|PubMed:31370103, ECO:0000269|PubMed:9845349}.; FUNCTION: [Isoform 2]: Lacks sodium- and chloride-dependent glycine transporter activity. {ECO:0000269|PubMed:10381548}.; FUNCTION: [Isoform 3]: Lacks sodium- and chloride-dependent glycine transporter activity. {ECO:0000269|PubMed:10381548}.
