基因名称(Gene Name)
TSPAN4,NAG2,TM4SF7
蛋白名称
Tetraspanin-4 (Tspan-4) (Novel antigen 2) (NAG-2) (Transmembrane 4 superfamily member 7)
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
背景
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
功能
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells (PubMed:31371828). Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells (PubMed:31371828). Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis (PubMed:36252000, PubMed:36823145). May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling (PubMed:34439793). {ECO:0000269|PubMed:31371828, ECO:0000269|PubMed:34439793, ECO:0000269|PubMed:36252000, ECO:0000269|PubMed:36823145}.
