蛋白名称
Baculoviral IAP repeat-containing protein 3
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:200-1:500; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
AIP 1 ; AIP1 ; API 2 ; API2 ; API2 ; Apoptosis inhibitor 2 ; Baculoviral IAP repeat containing 3 ; Baculoviral IAP repeat containing protein 3 ; Baculoviral IAP repeat-containing protein 3 ; BIRC 3 ; BIRC3 ; BIRC3 ; BIRC3_HUMAN ; C IAP2 ; C-IAP2 ; CIAP 2 ; CIAP 2 ; CIAP2 ; HAIP 1 ; HAIP1 ; HAIP1 ; HIAP 1 ; HIAP-1 ; HIAP1 ; IAP homolog C ; IAP-1 ; Inhibitor of apoptosis protein 1 ; Inhibitor of apoptosis protein 1 ; MALT 2 ; MALT2 ; Mammalian IAP homolog C ; MIHC ; MIHC ; RING finger protein 49 ; RNF49 ; TNFR2 TRAF signaling complex protein 1 ; TNFR2 TRAF signalling complex protein ; TNFR2-TRAF-signaling complex protein 1.
背景
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011],
功能
Disease:A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,Function:Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).,similarity:Belongs to the IAP family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.,tissue specificity:Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.,
