蛋白名称
Eukaryotic translation initiation factor 2-alpha kinase 4
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:100-1:500; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
EIF2AK4 ; GCN2 ; KIAA1338 ; Eukaryotic translation initiation factor 2-alpha kinase 4 ; GCN2-like protein
背景
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014],
功能
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Domain:Kinase domain 1 is a degenerate kinase domain.,Domain:RWD domain is reported to interact with GCN1L1.,Function:Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.,PTM:Autophosphorylated on threonine residues.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.,similarity:Contains 1 RWD domain.,similarity:Contains 2 protein kinase domains.,tissue specificity:Widely expressed.,
