基因名称(Gene Name)
PRDX6 AOP2 KIAA0106
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
Peroxiredoxin-6 ; 1-Cys peroxiredoxin ; 1-Cys PRX ; 24 kDa protein ; Acidic calcium-independent phospholipase A2 ; aiPLA2 ; Antioxidant protein 2 ; Liver 2D page spot 40 ; Non-selenium glutathione peroxidase ; NSGPx ; Red blood cells page spot 12 ;
背景
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008],
功能
Catalytic activity:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.,Catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,Function:Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.,miscellaneous:Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress.,miscellaneous:The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.,similarity:Belongs to the ahpC/TSA family. Rehydrin subfamily.,similarity:Contains 1 thioredoxin domain.,subcellular location:And also found in lung secretory organelles.,subunit:Homotetramer. May interact with HTR2A (By similarity). Interacts with STH.,
