基因名称(Gene Name)
LCN2 HNL NGAL
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Monoclonal, Rabbit,IgG
稀释比例
IHC 1:1000-1:4000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
Neutrophil gelatinase-associated lipocalin ; NGAL ; 25 kDa alpha-2-microglobulin-related subunit of MMP-9 ; Lipocalin-2 ; Oncogene 24p3 ; Siderocalin LCN2 ; p25 ;
背景
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015],
功能
Transport of small lipophilic substances .,similarity:Belongs to the calycin superfamily. Lipocalin family.,subunit:Forms a covalently linked, disulfide-bridged heterodimer with the 92 kDa type V collagenase (MMP-9).,tissue specificity:Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lungs. Not found in the small intestine or peripheral blood leukocytes.,
