背景
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from
phosphatidylinositol 4,5-bisphosphate . This reaction uses calcium as a cofactor and plays an important role in the
intracellular transduction of receptor-mediated tyrosine kinase activators . For example, when activated by SRC, the
encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it
activates Ras . Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic
fbroblast growth factor)-activated tyrosine kinase . Two transcript variants encoding diferent isoforms have been
found for this gene .
