基因名称(Gene Name)
SMARCA1 SNF2L SNF2L1
蛋白名称
Probable global transcription activator SNF2L1 (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
免疫原
Synthesized peptide derived from human SNF2L. AA range:885-955
特异性
This antibody detects endogenous levels of SNF2L at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
SMARCA1 SNF2L SNF2L1;Probable global transcription activator SNF2L1 (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
功能
[Isoform 1]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity . Acts as a negative regulator of chromatin remodelers by generating inactive complexes . ; [Isoform 2]: Helicase that possesses intrinsic ATP-dependent chromatin-remodeling activity . ATPase activity is substrate-dependent , and is increased when nucleosomes are the substrate , but is also catalytically active when DNA alone is the substrate . Catalytic subunit of ISWI chromatin-remodeling complexes , which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication , transcription , and repair . Within the ISWI chromatin-remodeling complexes , slides edge- and center-positioned histone octamers away from their original location on the DNA template . Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes . The BAZ1A- , BAZ1B- , BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template . The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template . Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes , nucleosomes are the preferred substrate for its ATPase activity . Within the NURF-1 ISWI chromatin-remodeling complex , binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development . May promote neurite outgrowth . May be involved in the development of luteal cells .
