基因名称(Gene Name)
PF4 CXCL4 SCYB4
蛋白名称
Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form]
免疫原
The specific immunogen used to produce this antibody is proprietary information.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
PF4 CXCL4 SCYB4;Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form];Platelet factor 4 ;
PF-4 ;
C-X-C motif chemokine 4 ;
Iroplact ;
Oncostatin-A ;
[Cleaved into: Platelet factor 4,short form]
背景
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis , angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq , Oct 2014] ,
功能
Function:Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation , the short form is a more potent inhibitor than the longer form. ,mass spectrometry: PubMed:7644496 ,mass spectrometry:Short form PubMed:7644496 ,online information:CXCL4 entry ,PTM:Binds non-covalently to a proteoglycan molecule. ,similarity:Belongs to the intercrine alpha (chemokine CxC) family. ,subunit:Homotetramer. ,
