背景
The protein encoded by this gene stimulates the activity of several transcription factors and
nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and
glucocorticoid receptor .The encoded protein may be involved in fat oxidation, non-oxidative
glucose metabolism, and the regulation of energy expenditure .This protein is
downregulated in prediabetic and type 2 diabetes mellitus patients . Certain allelic variations
in this gene increase the risk of the development of obesity .Three transcript variants
encoding different isoforms have been found for this gene .
