免疫原
Recombinant protein (or fragment).This information is considered to be commercially
sensitive .
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085
背景
The scaffolding protein encoded by this gene is the main component of the caveolae plasma
membranes found in most cell types .The protein links integrin subunits to the tyrosine
kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting
cell cycle progression .The gene is a tumor suppressor gene candidate and a negative
regulator of the Ras-p42/44 mitogen-activated kinase cascade . Caveolin 1 and caveolin 2 are
located next to each other on chromosome 7 and express colocalizing proteins that form a
stable hetero-oligomeric complex . Mutations in this gene have been associated with
Berardinelli-Seip congenital lipodystrophy . Alternatively spliced transcripts encode alpha and
beta isoforms of caveolin 1.
