基因名称(Gene Name)
FBXO9 FBX9 VCIA1
蛋白名称
F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57)
免疫原
Synthesized peptide derived from human FBXO9. AA range:64-164
特异性
This antibody detects endogenous levels of FBXO9 at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
FBXO9 FBX9 VCIA1;F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57)
功能
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner , thereby directly regulating mTOR signaling. SCF (FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation , leading to their degradation. In contrast , the SCF (FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence , mTORC1 is inactivated to restrain cell growth and protein translation , while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
