背景
In vertebrates, the genes encoding the class of transcription factors called homeobox genes
are found in clusters named A, B, C, and D on four separate chromosomes. Expression of
these proteins is spatially and temporally regulated during embryonic development.This
gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription
factor which may regulate gene expression, morphogenesis, and differentiation. Expansion
of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also
known as hand-foot-genital syndrome.
