基因名称(Gene Name)
ATP2B1 PMCA1
蛋白名称
Plasma membrane calcium-transporting ATPase 1 (PMCA1) (Plasma membrane calcium ATPase isoform 1) (Plasma membrane calcium pump isoform 1)
免疫原
The specific immunogen used to produce this antibody is proprietary information.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
ATP2B1 PMCA1;Plasma membrane calcium-transporting ATPase 1 (PMCA1) (Plasma membrane calcium ATPase isoform 1) (Plasma membrane calcium pump isoform 1)
功能
Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity) . Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells . May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.
