背景
This gene encodes a member of the cytochrome P450 superfamily of enzymes.The
cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in
drug metabolism and synthesis of cholesterol, steroids and other lipids.The protein encoded
by this gene localizes to the endoplasmic reticulum and its expression is induced by some
polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke.The
enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to
carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine,
aflatoxin B1, and acetaminophen.The transcript from this gene contains four Alu sequences
flanked by direct repeats in the 3' untranslated region.
