背景
This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme
selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate
proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently
localized to the cell surface. The expression of this gene may be down-regulated in several
types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative
splicing results in multiple transcript variants.
