背景
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes.The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments.Through its rod domain, this protein forms complexes with envoplakin.This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments.AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
