背景
This gene encodes a member of the beta chemokine receptor family, which is predicted to
be a seven transmembrane protein similar to G protein-coupled receptors.The ligands of
this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on
activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant
protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their
receptors mediated signal transduction are critical for the recruitment of effector immune
cells to the site of inflammation. Knockout studies of the mouse homolog suggested the
roles of this gene in host protection from inflammatory response, and susceptibility to virus
and parasite.This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3,
CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.
