背景
This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose
members include the bee venom enzyme.The encoded enzyme functions in lipid
metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of
phospholipids to release arachidonic acid and lysophospholipids.This enzyme acts as a
negative regulator of ciliogenesis, and may play a role in cancer development by stimulating
tumor cell growth and angiogenesis.This gene is associated with oxidative stress, and
polymorphisms in this gene are linked to risk for Alzheimer's disease.
