背景
The protein encoded by this gene functions as a transcriptional coactivator for nuclear
hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors.The
encoded protein acts as an intermediary factor for the ligand-dependent activity of these
nuclear receptors, which regulate their target genes upon binding of cognate response
elements.This gene has been found to be involved in translocations that result in fusions
with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene
in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia,
and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in
mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.
