基因名称(Gene Name)
LAPTM4B PSEC0001
蛋白名称
Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta)
免疫原
Synthesized peptide derived from human LAPTM4B. AA range:24-124
特异性
This antibody detects endogenous levels of LAPTM4B at Human, Mouse,Rat
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Required for optimal lysosomal function . Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4 ,5-bisphosphate , regulates its PIP5K1C interaction , inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation . Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome , promoting entry of leucine and other essential amino acid (EAA) into the lysosome , stimulating activation of proton-transporting vacuolar (V) -ATPase protein pump (V-ATPase) and hence mTORC1 activation . Plays a role as negative regulator of TGFB1 production in regulatory T cells . Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways .
