背景
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like
receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The
ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4,
thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein
can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I
to the inflammasome complex.
