免疫原
Synthetic peptide. This information is considered to be commercially sensitive.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD;
ADTKD2; Ca15-3; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; MUC1
背景
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins
are O-glycosylated proteins that play an essential role in forming protective mucous barriers
on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is
expressed on the apical surface of epithelial cells that line the mucosal surfaces of many
different tissues including lung, breast stomach and pancreas. This protein is proteolytically
cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal
alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell
signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of
this protein have been associated with carcinomas. This gene is known to contain a highly
polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in
multiple transcript variants.
