背景
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated
ion channels from both functional and structural standpoints. Their diverse functions include
regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,
epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequencerelated potassium channel genes - shaker, shaw, shab, and shal - have been identified in
Drosophila, and each has been shown to have human homolog(s). This gene encodes a
member of the potassium channel, voltage-gated, shaker-related subfamily. This member is
one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha
subunits. This member alters functional properties of the KCNA4 gene product. Alternative
splicing of this gene results in multiple transcript variants encoding distinct isoforms.
