其他名称
DnaJ protein Tid 1;DNAJA3;HCA57;hTid 1;TID 1;TID1;DNAJA3 HCA57 TID1;DnaJ homolog subfamily A member 3;mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog);SRA;SR-A;CD204;SR-AI;phSR1;phSR2;SCARA1;SR-AII;SR-AIII;MSR1
背景
This gene encodes the class A macrophage scavenger receptors, which include three
different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or
isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been
implicated in many macrophage-associated physiological and pathological processes
including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and
type 2 are functional receptors and are able to mediate the endocytosis of modified low
density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetylLDL) despite having the domain shown to mediate this function in the types 1 and 2
isoforms. It has an altered intracellular processing and is trapped within the endoplasmic
reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the
function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative
effect and suggesting a mechanism for regulation of scavenger receptor activity in
macrophages.
